Noda M, Inaba Y, Seno M, Kanamoto Y, Tokumoto S
Division of 2nd Microbiology, Hiroshima Prefectural Institute of Public Health and Environment Science, Japan.
Microbiol Immunol. 1993;37(12):979-81. doi: 10.1111/j.1348-0421.1993.tb01733.x.
Heparin inhibited the hemagglutinin activity of herpes simplex virus (HSV) type 1. The minimal inhibitory concentration of heparin required to inhibit 8 hemagglutination (HA) U of HSV ranged from 0.005 to 0.01 U/ml. Mouse erythrocytes failed to combine with the HA inhibitory factor of heparin. On the other hand, mouse erythrocytes treated with heparinase had greatly reduced agglutinability by HSV. Virus-heparin complex formation was observed by sedimenting heparin with the virus particles.
肝素抑制了1型单纯疱疹病毒（HSV）的血凝素活性。抑制8个血凝单位（HA）的HSV所需的肝素最小抑制浓度范围为0.005至0.01 U/ml。小鼠红细胞未能与肝素的HA抑制因子结合。另一方面，用肝素酶处理的小鼠红细胞被HSV凝集的能力大大降低。通过将肝素与病毒颗粒一起沉淀观察到病毒-肝素复合物的形成。
