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Pharmacogenetics: the slow, the rapid, and the ultrarapid.

作者信息

Meyer U A

机构信息

Department of Pharmacology, University of Basel, Switzerland.

出版信息

Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):1983-4. doi: 10.1073/pnas.91.6.1983.

DOI:10.1073/pnas.91.6.1983
PMID:8134334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC43291/
Abstract
摘要

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本文引用的文献

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Drug reactions enzymes, and biochemical genetics.药物反应、酶与生化遗传学
J Am Med Assoc. 1957 Oct 19;165(7):835-7. doi: 10.1001/jama.1957.72980250010016.
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A method for the detection of atypical forms of human serum cholinesterase; determination of dibucaine numbers.一种检测人血清胆碱酯酶非典型形式的方法；地布卡因值的测定。
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Enzymatic deficiency in primaquine-sensitive erythrocytes.伯氨喹敏感红细胞中的酶缺乏。
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Localization of the CYP2D gene locus to human chromosome 22q13.1 by polymerase chain reaction, in situ hybridization, and linkage analysis.通过聚合酶链反应、原位杂交和连锁分析将CYP2D基因座定位于人类染色体22q13.1。
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Regulation and mechanisms of mammalian gene amplification.哺乳动物基因扩增的调控与机制。
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6
Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.在日本人群中发现一种新的CYP2D6变异等位基因CYP2D6J，其与司巴丁体内代谢率降低相关的证据。
Pharmacogenetics. 1993 Oct;3(5):256-63. doi: 10.1097/00008571-199310000-00005.
7
Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene.异喹胍氧化多态性：CYP2D6基因第5外显子3个碱基对缺失的表型后果。
Pharmacogenetics. 1993 Jun;3(3):123-30.
8
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.细胞色素P450 CYP2D基因座中一个活性基因的遗传性扩增是导致异喹胍超快代谢的原因。
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11825-9. doi: 10.1073/pnas.90.24.11825.
9
Amplification of an esterase gene is responsible for insecticide resistance in a California Culex mosquito.酯酶基因的扩增导致加利福尼亚库蚊对杀虫剂产生抗性。
Science. 1986 Aug 15;233(4765):778-80. doi: 10.1126/science.3755546.
10
Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.高等真核生物中DNA的过度复制与重组：潜在后果及生物学意义
Proc Natl Acad Sci U S A. 1986 Apr;83(7):2157-61. doi: 10.1073/pnas.83.7.2157.