高等真核生物中DNA的过度复制与重组：潜在后果及生物学意义
Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.
作者信息
Schimke R T, Sherwood S W, Hill A B, Johnston R N
出版信息
Proc Natl Acad Sci U S A. 1986 Apr;83(7):2157-61. doi: 10.1073/pnas.83.7.2157.
Abstract
We propose that a fundamental problem in the faithful replication of complex chromosomes of higher eukaryotes is the proper control of both the number and timing of the multiple initiations of replication on single chromosomes. When replication patterns are disrupted by any of a variety of agents, overreplication of DNA can occur. We propose a model that accounts for the generation of a wide variety of chromosomal aberrations-rearrangements, resulting from the various ways in which the overreplicated strands can undergo recombination. We also discuss certain implications of the generation of chromosomal alterations in higher eukaryotes as they may relate to cancer chemotherapy, cancer progression, aging, and rapid speciation-evolution.
摘要
我们提出，高等真核生物复杂染色体忠实复制中的一个基本问题是对单条染色体上多个复制起始点的数量和时间进行恰当控制。当复制模式被多种因素中的任何一种破坏时，就可能发生DNA的过度复制。我们提出了一个模型，该模型解释了由于过度复制的链进行重组的各种方式而导致的多种染色体畸变——重排的产生。我们还讨论了高等真核生物中染色体改变的产生可能与癌症化疗、癌症进展、衰老以及快速物种形成——进化相关的某些影响。
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