Carey T E, Van Dyke D L, Worsham M J
Department of Otolaryngology Head and Neck Surgery, University of Michigan Cancer Center, Ann Arbor 48109-0506.
Anticancer Res. 1993 Nov-Dec;13(6B):2561-7.
Losses of 3p13-p24, 5q12-q23, 8p22-p23, 9p21-p24, 10p13-pter, 18q22-q23, and 21q11.2-q21 (40-60% of tumors); loss of the inactive X and loss (or rearrangement) of Y in 70% of tumors from female and male patients respectively; and gains of 2 to 5 extra copies of 3q21-qter, 5p14-pter, 7p13-p22, 8q13-q24.3, and 11q13-q23, (30-40% of tumors) are the most common chromosome abnormalities in head and neck squamous cell carcinomas (SCCs). SCCs are monoclonal and cell lines derived from separate surgeries in the same patient contain closely related subclones. Analysis of subclones within tumors provides clues to the sequence of karyotypic changes. Chromosome hotspots such as loss of distal 18q and gains affecting 11q13-11q21 are likely to contain genes important in the development and progression of SCC.
3p13-p24、5q12-q23、8p22-p23、9p21-p24、10p13-染色体末端、18q22-q23和21q11.2-q21缺失（在40%-60%的肿瘤中出现）；在女性和男性患者的肿瘤中，分别有70%的肿瘤出现失活X染色体缺失以及Y染色体缺失（或重排）；3q21-染色体末端、5p14-染色体末端、7p13-p22、8q13-q24.3和11q13-q23出现2至5个额外拷贝增加（在30%-40%的肿瘤中出现），这些是头颈部鳞状细胞癌（SCC）中最常见的染色体异常情况。SCC是单克隆性的，来自同一患者不同手术的细胞系含有密切相关的亚克隆。对肿瘤内亚克隆的分析为核型变化的顺序提供了线索。染色体热点区域，如18号染色体长臂远端缺失以及影响11q13-11q21的增加，可能包含在SCC发生发展中起重要作用的基因。
