Contreras Rodríguez R, Rodríguez Velasco A, Flores Miranda J R, Ramos Amaro J
Departamento de Patología, Hospital Juárez de México, México D.F.
Arch Inst Cardiol Mex. 1993 Nov-Dec;63(6):485-91.
We studied the role of bacterial endocarditis in the development of aortic valve stenosis. A femoral arterio venous shunt was performed in nine dogs with the method previously proposed by Lillehei. We induced bacteremic infection with the administration of streptococcus mitis (1 x 10(10)) 10 ml once a day for 15 days these bacterium were sensible to penicillin. All dogs were treated with 1,000,000 U of benzatinic penicillin and sacrificed between 28-102 days after the bacterial inoculation ended. In one dog we observed bacterial endocarditis in the mitral and aortic valves and in other three dogs there was an aortic valve stenosis with calcium deposits in the body and in the free edges of the aortic valve with evident irregular stenosis as seen in man.
我们研究了细菌性心内膜炎在主动脉瓣狭窄发展过程中的作用。采用利勒黑先前提出的方法，对9只狗进行了股动静脉分流术。我们通过每天一次给予10毫升缓症链球菌（1×10¹⁰）诱导菌血症感染，持续15天，这些细菌对青霉素敏感。所有狗均接受100万单位苄星青霉素治疗，并在细菌接种结束后28至102天之间处死。在1只狗中，我们观察到二尖瓣和主动脉瓣有细菌性心内膜炎，在另外3只狗中，出现了主动脉瓣狭窄，在主动脉瓣体部和游离缘有钙沉积，呈现出如人类所见的明显不规则狭窄。
