[血液乙醇水平与CTP2E1 C2等位基因]

[Blood ethanol levels and the CTP2E1 C2 allele].

作者信息

Iwahashi K, Miyatake R, Suwaki H, Kinoshita H, Ameno K, Ijiri I, Ishikawa Y, Matsuo Y

机构信息

Department of Neuropsychiatry, Kagawa Medical School, Japan.

出版信息

Arukoru Kenkyuto Yakubutsu Ison. 1994 Jun;29(3):190-4.

PMID:8080402

Abstract

The effect of CYP2E1 upon the blood ethanol level was investigated. Blood ethanol concentrations in 2 volunteers whose ADH2, ADH3 and ALDH2 genotypes were identical, were determined after intravenous administrations of 0.15 g/kg of ethanol by gas chromatography. beta 60 (0.28 mg/ml/hr) of the blood ethanol concentration-time curve in one with the CYP2E1 C2 allele was higher than that (0.25 mg/ml/hr) in the other with no C2 allele. It is possible that the C2 allele may correspond to the higher CYP2E1 activity of ethanol metabolism.

摘要

研究了CYP2E1对血液乙醇水平的影响。通过气相色谱法，在两名ADH2、ADH3和ALDH2基因型相同的志愿者静脉注射0.15 g/kg乙醇后，测定其血液乙醇浓度。携带CYP2E1 C2等位基因的一名志愿者的血液乙醇浓度-时间曲线的β60（0.28 mg/ml/hr）高于另一名无C2等位基因志愿者的曲线（0.25 mg/ml/hr）。C2等位基因可能与乙醇代谢中较高的CYP2E1活性相对应。