三种不同培养基上淋病奈瑟菌对甲氧苄啶-磺胺甲恶唑的体外药敏比较。
Comparison of in vitro susceptibility of Neisseria gonorrhoeae to trimethoprim-sulfamethoxazole on three different media.
作者信息
Yoshikawa T T, Miyamoto S, Guze L B
出版信息
Antimicrob Agents Chemother. 1975 Nov;8(5):515-7. doi: 10.1128/AAC.8.5.515.
Abstract
In vitro susceptibility of 100 clinical isolates of Neisseria gonorrhoeae to trimethoprim-sulfamethoxazole (TMP-SMZ combination; 1:19) was determined by the agar dilution technique using three different media under similar conditions. On Oxoid diagnostic sensitivity test, Mueller-Hinton, and GC agar media, the percentage of isolates inhibited by 2.5 mug or less of TMP per ml and 47.5 mug or less of SMZ per ml were 95, 90, and 84%, respectively. TMP-SMZ appeared to be effective in vitro against N. gonorrhoeae despite differences in the types of media used.
摘要
采用琼脂稀释法，在相似条件下使用三种不同培养基，测定了100株淋病奈瑟菌临床分离株对甲氧苄啶-磺胺甲恶唑（TMP-SMZ合剂，1:19）的体外敏感性。在Oxoid诊断敏感性试验培养基、穆勒-欣顿培养基和GC琼脂培养基上，每毫升2.5微克或更低剂量的TMP以及每毫升47.5微克或更低剂量的SMZ所抑制的分离株百分比分别为95%、90%和84%。尽管所用培养基类型不同，但TMP-SMZ在体外似乎对淋病奈瑟菌有效。
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