淋病奈瑟菌的多重抗生素耐药性。
Multiple antibiotic resistance in Neisseria gonorrhoeae.
作者信息
Maier T W, Beilstein H R, Zubrzycki L
出版信息
Antimicrob Agents Chemother. 1974 Jul;6(1):22-8. doi: 10.1128/AAC.6.1.22.
The sensitivities of gonococcal isolates to six antibiotics were determined for gonococci isolated in Philadelphia in 1972. The degree of association between susceptibilities to any two antibiotics was determined (coefficient of correlation). The correlation between penicillin and tetracycline (r = 0.75) was almost as good as that between two penicillins, penicillin G and ampicillin (r = 0.85), but the difference was statistically significant. The lowest correlation found was between erythromycin and chloramphenicol (r = 0.62), two antibiotics seldom used in gonorrhea therapy. In addition, gonococci most resistant to one antibiotic were the most likely to be multiply resistant. This was found with respect to penicillin, tetracycline, erythromycin, and chloramphenicol. Approximately 40% of gonococci classified as "most resistant" (exceeding the resistance of 75% of all isolates) to one antibiotic were also "most resistant" to three others. Finally, multiply resistant mutants were isolated by selection for resistance to either penicillin or tetracycline. These results provide evidence for the existence of a common mechanism for multiple antibiotic resistance in the gonococcus.
对1972年在费城分离出的淋球菌进行了淋球菌分离株对六种抗生素的敏感性测定。确定了对任意两种抗生素敏感性之间的关联程度（相关系数）。青霉素和四环素之间的相关性（r = 0.75）几乎与两种青霉素（青霉素G和氨苄青霉素，r = 0.85）之间的相关性一样好，但差异具有统计学意义。发现相关性最低的是红霉素和氯霉素（r = 0.62），这两种抗生素很少用于淋病治疗。此外，对一种抗生素耐药性最强的淋球菌最有可能具有多重耐药性。在青霉素、四环素、红霉素和氯霉素方面均发现了这一情况。被归类为对一种抗生素“耐药性最强”（超过所有分离株的75%的耐药性）的淋球菌中，约40%对其他三种抗生素也“耐药性最强”。最后，通过选择对青霉素或四环素的耐药性分离出了多重耐药突变体。这些结果为淋球菌多重抗生素耐药性存在共同机制提供了证据。
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