• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一类潜在防晒剂5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮的合成及体外光毒性

Synthesis and in vitro phototoxicity of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones, a class of potential sunscreens.

作者信息

Mariani E, Schenone P, Guarrera M, Dorato S

机构信息

Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.

出版信息

Farmaco. 1993 Dec;48(12):1687-95.

PMID:8135992
Abstract

A series of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6- ones was prepared by reaction of (+)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-one with aromatic aldehydes in an alkaline medium. These compounds can be considered as potential UVB or UVA sunscreens. In vitro phototoxicity tests (photohemolysis and Candida albicans) showed that they exhibit in general a low phototoxicity level.

摘要

通过在碱性介质中使（+）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮与芳香醛反应，制备了一系列5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮。这些化合物可被视为潜在的中波紫外线（UVB）或长波紫外线（UVA）防晒剂。体外光毒性试验（光溶血和白色念珠菌试验）表明，它们总体上表现出低光毒性水平。

相似文献

1
Synthesis and in vitro phototoxicity of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones, a class of potential sunscreens.一类潜在防晒剂5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮的合成及体外光毒性
Farmaco. 1993 Dec;48(12):1687-95.
2
Synthesis of ethylammonium iodides of omega-dialkylaminoethyl ethers of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo [2.2.2.] octan-6-hydroxyimines as potential cosmetic ingredients.5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基亚胺的ω-二烷基氨基乙基醚的碘化乙铵盐作为潜在化妆品成分的合成
Boll Chim Farm. 1996 May;135(5):335-41.
3
5-[4-(omega-dialkylaminoalkoxy)phenylmethylene] -1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones with platelet antiaggregating and other activities.具有血小板抗聚集及其他活性的5-[4-(ω-二烷基氨基烷氧基)苯亚甲基]-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮
Farmaco. 1991 May;46(5):657-68.
4
omega-Dialkylaminoalkyl ethers of 5-(arylmethylene)-1,3,3-trimethyl-2- oxabicyclo[2.2.2]octan-6-hydroxyimines with platelet antiaggregating and other activities.5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基亚胺的ω-二烷基氨基烷基醚，具有抗血小板聚集及其他活性。
Farmaco. 1991 Jan;46(1):85-98.
5
5-[[omega-(Dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2- oxabicyclo [2.2.2.]octan-6-ones with hypotensive, local anesthetic, antiarrhythmic and other activities.具有降压、局部麻醉、抗心律失常及其他活性的5-[[ω-(二烷基氨基)烷氧基]亚甲基]-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮
Farmaco. 1994 Sep;49(9):541-4.
6
omega-Dialkylaminoalkyl ethers of 6-(benzyl or phenyl)-1,3,3-trimethyl-2-oxabicyclo [2.2.2]octan-6-ol with platelet antiaggregating and local anesthetic activities.6-（苄基或苯基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-醇的ω-二烷基氨基烷基醚，具有血小板抗聚集和局部麻醉活性。
Farmaco. 1990 Dec;45(12):1309-25.
7
omega-Dialkylaminoalkyl ethers of 5-endo-dialkylamino-1,3,3-trimethyl-2-oxabicyclo [2.2.2]octan-6-hydroxyimines with platelet antiaggregating, antiarrhythmic and local anesthetic activities.5-内-二烷基氨基-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基胺的ω-二烷基氨基烷基醚，具有血小板抗聚集、抗心律失常和局部麻醉活性。
Farmaco. 1990 Sep;45(9):1013-25.
8
1,3,3-Trimethyl-N-(2-pyridyl)-2-oxabicyclo[2.2.2]octan-6-amine derivatives with hypotensive and other activities.具有降压及其他活性的1,3,3-三甲基-N-(2-吡啶基)-2-氧杂双环[2.2.2]辛烷-6-胺衍生物
Farmaco Sci. 1986 Jun;41(6):454-63.
9
Aminoethers of (+)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]-octan-6-hydroxyimine with hypotensive activity. II.具有降压活性的（+）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基亚胺的氨基醚。II.
Farmaco Sci. 1986 Aug;41(8):630-6.
10
N-substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo [2.2.2]-octan-6-ones with platelet antiaggregating and local anesthetic activities.1,3,3-三甲基-5-内-(1-哌啶基或4-吗啉基)-2-氧杂双环[2.2.2]辛烷-6-酮的N-取代O-(3-氨基-2-羟丙基)肟，具有血小板抗聚集和局部麻醉活性。
Farmaco. 1992 Oct;47(10):1249-62.