Mariani E, Bargagna A, Longobardi M, Neuhoff C, Rizzetto R, Dorato S
Istituto di Scienze Farmaceutiche dell' Università, Genova, Italy.
Boll Chim Farm. 1996 May;135(5):335-41.
The synthesis of nine quaternary ammonium iodides derived from omega-dialkylaminoethyl ethers of 5-(arylmethylene)-1,3, 3-trimethyl-2-oxabicyclo[2.2.2]octan-6-hydroxyimines, as potential cosmetic ingredients, is described. They are routinely prepared starting from cineole aminoethers by reaction with iodoethane and their physics-chemical data are reported. These substances were studied for their UV absorption and three of these compounds were also submitted to microbiological assays on five test organisms. The substances have their UV absorption maxima at 284-321 nm, and one compound is active on Staphylococcus aureus, Streptococcus faecalis and Candida albicans. These preliminary findings seem to indicate that some of these compounds could be considered as potential UV sunscreens; one compound, having a moderate antimicrobial activity, could be considered a potential active compound in cosmetics as deodorants, toothpastes, mouthwashes and other oral care products.
本文描述了9种由5-(芳基亚甲基)-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基亚胺的ω-二烷基氨基乙醚衍生而来的碘化季铵盐的合成，这些碘化季铵盐作为潜在的化妆品成分。它们通常由桉叶油素氨基醚与碘乙烷反应制备，并报告了其物理化学数据。研究了这些物质的紫外线吸收情况，其中三种化合物还针对五种测试微生物进行了微生物检测。这些物质的紫外线吸收最大值在284-321nm之间，有一种化合物对金黄色葡萄球菌、粪肠球菌和白色念珠菌有活性。这些初步研究结果似乎表明，其中一些化合物可被视为潜在的紫外线防晒剂；有一种具有适度抗菌活性的化合物，可被视为化妆品中除臭剂、牙膏、漱口水和其他口腔护理产品的潜在活性化合物。
