Craig S R, Walker W S
Department of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Scotland, UK.
Eur J Cardiothorac Surg. 1994;8(1):43-5. doi: 10.1016/1010-7940(94)90132-5.
Over a 3-year period 17 patients underwent a total of 25 coronary artery bypass grafts utilising bovine internal mammary artery [BIOFLOW]. Three patients died in the peri-operative or early post-operative period allowing detailed information to be gathered on 14 patients. Seven patients who had had a total of 11 Bioflow grafts implanted underwent post-operative coronary angiography at a mean time of 19 months after surgery revealing occlusion in all the Bioflow grafts. Two patients who underwent aortic valve replacement combined with single Bioflow grafts were symptom-free and refused re-study. Two patients who had three coronary grafts each, including single Bioflow grafts, refused re-study though one of them had recurrent anginal symptoms. Two patients, one with recurrent anginal symptoms, who had a total of four Bioflow grafts were considered unfit for restudy on medical (non-cardiac) grounds. One patient with two Bioflow grafts and recurrent symptoms refused long-term follow-up. Despite reports of good early patency rates with the Bioflow graft, we have not found this to be the case even when patients were anticoagulated post-operatively. We do not recommend the use of this graft as early occlusion is to be expected, which may result in an early return of anginal symptoms.
在3年期间，17例患者共接受了25次使用牛乳内动脉[BIOFLOW]的冠状动脉旁路移植术。3例患者在围手术期或术后早期死亡，从而能够收集到14例患者的详细信息。7例共植入了11个Bioflow移植物的患者在术后平均19个月时接受了冠状动脉造影，结果显示所有Bioflow移植物均发生闭塞。2例接受主动脉瓣置换术并联合单个Bioflow移植物的患者无症状且拒绝再次检查。2例各有3个冠状动脉移植物（包括单个Bioflow移植物）的患者拒绝再次检查，尽管其中1例有复发性心绞痛症状。2例共有4个Bioflow移植物的患者（其中1例有复发性心绞痛症状）因医学（非心脏）原因被认为不适合再次检查。1例有2个Bioflow移植物且有复发性症状的患者拒绝长期随访。尽管有报道称Bioflow移植物早期通畅率良好，但我们发现即使患者术后接受抗凝治疗也并非如此。我们不建议使用这种移植物，因为预计会早期闭塞，这可能导致心绞痛症状早期复发。
