Sancho Serrano M A, Jiménez Aznarez A, Sanz París A
Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario, Zaragoza.
An Med Interna. 1993 Oct;10(10):479-83.
Disorders of the lipoprotein metabolism in diabetic patients are of great interest because their association to the presence of atheromatosis and because cardiovascular diseases are the major cause of mortality in diabetic patients. The aim of this study was to compare the lipidic scheme of our diabetic patients according to the type of diabetes, the age of onset and the evolution over the years, and to analyze the impact of variations in the glycemic control on such lipidic scheme. In the insulin-dependent diabetes mellitus, total cholesterol, LDL, HDL and triglycerides were within the recommended values for the age of the patients. There was a significant correlation between glycemia and HbAlc and triglycerides, total cholesterol and its LDL and HDL fractions. In non-insulin-dependent diabetes mellitus, we observed average values of total cholesterol and LDL fraction higher than what is recommended for diabetic patients with the characteristics of this group. There was a significant correlation between basal glycemia, HbAlc and triglycerides, as in the insulin-dependent diabetes, although there was no correlation with total cholesterol and HDL. This absence of correlation may be due to the effect of other factors: age, inadequate dietary follow-up obesity and hyperinsulinism.
糖尿病患者的脂蛋白代谢紊乱备受关注,因为它们与动脉粥样硬化的存在相关,且心血管疾病是糖尿病患者死亡的主要原因。本研究的目的是根据糖尿病类型、发病年龄和多年来的病情发展,比较我们糖尿病患者的血脂情况,并分析血糖控制变化对这种血脂情况的影响。在胰岛素依赖型糖尿病中,总胆固醇、低密度脂蛋白、高密度脂蛋白和甘油三酯在患者年龄的推荐值范围内。血糖与糖化血红蛋白以及甘油三酯、总胆固醇及其低密度脂蛋白和高密度脂蛋白组分之间存在显著相关性。在非胰岛素依赖型糖尿病中,我们观察到总胆固醇和低密度脂蛋白组分的平均值高于具有该组特征的糖尿病患者的推荐值。与胰岛素依赖型糖尿病一样,基础血糖、糖化血红蛋白与甘油三酯之间存在显著相关性,尽管与总胆固醇和高密度脂蛋白无相关性。这种无相关性可能是由于其他因素的影响:年龄、饮食随访不足、肥胖和高胰岛素血症。