Brazzelli V, Borroni G, Vignoli G P, Rabbiosi G, Cavagnino A, Berardesca E
Department of Dermatology, University of Pavia, IRCCS Policlinico S. Matteo, Italy.
Dermatology. 1994;188(2):113-6. doi: 10.1159/000247113.
Water plays an important role in maintaining skin suppleness and elasticity. We used hemodialysis as a model to investigate the effects on biophysical properties of the skin induced by removal of fluids and water from the body. The following parameters have been investigated before and immediately after a hemodialysis session: body weight, skin elasticity and distensibility, skin hydration, transepidermal water loss (TEWL) and skin thickness. A significant decrease was recorded after treatment in body weight, skin thickness (p < 0.01) and skin elasticity (p < 0.01). Significant linear correlations were found between stratum corneum water content, skin distensibility and TEWL. The data reveal that rapid removal of body fluids influences skin biophysical properties: early changes in skin thickness and ground substance occur in the dermis and affect mechanical properties of the skin. The decrease in water content in the upper layers of the skin occurs at a later stage and influences skin hydration rather than TEWL. This model is a useful tool to investigate water kinetics through the skin.
水在维持皮肤的柔软度和弹性方面起着重要作用。我们以血液透析作为模型，来研究从体内去除液体和水分对皮肤生物物理特性的影响。在血液透析疗程之前及结束后立即对以下参数进行了研究：体重、皮肤弹性和延展性、皮肤水合作用、经表皮水分流失（TEWL）以及皮肤厚度。治疗后，体重、皮肤厚度（p < 0.01）和皮肤弹性（p < 0.01）均出现显著下降。角质层含水量、皮肤延展性和TEWL之间存在显著的线性相关性。数据表明，快速去除体液会影响皮肤的生物物理特性：真皮中皮肤厚度和基质的早期变化会影响皮肤的机械性能。皮肤上层含水量的下降发生在后期，影响的是皮肤水合作用而非TEWL。该模型是研究水分通过皮肤的动力学的有用工具。
