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Multiple non-melanoma skin cancer: evidence that different MHC genes are associated with different cancers.

作者信息

Czarnecki D, Tait B, Nicholson I, Lewis A

机构信息

Repatriation General Hospital, Heidelberg, Australia.

出版信息

Dermatology. 1994;188(2):88-90. doi: 10.1159/000247107.

DOI:10.1159/000247107
PMID:8136554
Abstract

HLA DR frequencies of patients with multiple non-melanoma skin cancers were analysed. There were significant differences in the frequencies of HLA DR1, DR4 and DR7 between patients who only had basal cell carcinomas and patients who had both basal and squamous cell carcinomas. There were significant differences in the frequency of HLA DR53 between the two groups. This antigen is in linkage disequilibrium with HLA DR4 and DR7, and it is not possible to distinguish the primary susceptibility locus.

摘要

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2
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