Czarnecki D, Nicholson I, Tait B, Nash C
Repatriation General Hospital, Heidelberg, Vict., Australia.
Dermatology. 1993;187(1):16-8. doi: 10.1159/000247190.
An association between HLA DR4 and the development of multiple basal cell carcinomas (BCC) and malignant melanoma (MM) was detected in southern Australia. There were highly significant differences in HLA DR frequencies between patients with multiple BCCs and MM and matched patients with multiple BCCs only. These findings suggest that hereditary factors associated with the HLA system influence what types of multiple skin cancers people develop.
在澳大利亚南部，研究发现人类白细胞抗原DR4（HLA DR4）与多发性基底细胞癌（BCC）及恶性黑色素瘤（MM）的发生之间存在关联。多发性BCC和MM患者与仅患有多发性BCC的匹配患者相比，HLA DR频率存在高度显著差异。这些发现表明，与HLA系统相关的遗传因素会影响人们患何种类型的多发性皮肤癌。
