Sakai K, Hisanaga N, Huang J, Shibata E, Ono Y, Aoki T, Takagi H, Ando T, Yokoi T, Takeuchi Y
Nagoya City Public Health Research Institute, Japan.
Cancer. 1994 Apr 1;73(7):1825-35. doi: 10.1002/1097-0142(19940401)73:7<1825::aid-cncr2820730709>3.0.co;2-m.
Pulmonary fiber content of both asbestos and nonasbestos types were evaluated in Japanese patients with malignant pleural mesotheliomas.
Pulmonary fiber content was analyzed in 16 patients and 16 case-matched control subjects by transmission electron microscopy with energy-dispersive X-ray analysis using a low-temperature ashing procedure.
The geometric mean content of total asbestos was significantly higher in the patients (22.0 x 10(6) fibers/g dry lung) than in the control subjects (2.24 x 10(6) fibers/g dry lung) (P < 0.01). When the asbestos content was analyzed by fiber type, the geometric means were also consistently and significantly higher among the patients compared with the control subjects (P < 0.01). Results were as follows: (1) amosite: patients 3.94 times 10(6) versus control subjects 0.23 x 10(6); (2) crocidolite: patients 3.56 times 10(6) versus control subjects 0.35 times 10(6); (3) total amphiboles: patients 16.0 times 10(6) versus control subjects 0.77 times 10(6); and (4) chrysotile: patients 3.76 times 10(6) versus control subjects 1.01 times 10(6). However, when individual total asbestos content was considered, 7 of the 16 patients (44%) had levels lower than the highest value noted among the control subjects. Pulmonary fiber content of patients and control subjects also revealed the presence of nonasbestos fibers. The geometric mean of nonasbestos fibers was significantly higher in the patients (87.3 x 10(6)) than in control subjects (33.8 x 10(6)) (P < 0.01). The major type of nonasbestos fibers in both groups was aluminum silicates. The mean of ratios of nonasbestos fiber contents to total asbestos contents in the patients and control subjects was 7.0 and 17.3, respectively.
The results were mainly in agreement with the findings of earlier investigations, but fiber content of both chrysotile and nonasbestos fiber as well as those of amphibole asbestos were significantly higher in the patients than in the control subjects.
对日本恶性胸膜间皮瘤患者的石棉和非石棉类型的肺纤维含量进行了评估。
采用低温灰化程序，通过透射电子显微镜和能量色散X射线分析，对16例患者和16例病例匹配的对照者的肺纤维含量进行分析。
患者的总石棉几何平均含量（22.0×10⁶根纤维/克干肺）显著高于对照者（2.24×10⁶根纤维/克干肺）（P<0.01）。按纤维类型分析石棉含量时，患者的几何平均值也始终且显著高于对照者（P<0.01）。结果如下：（1）铁石棉：患者3.94×10⁶根纤维/克干肺，对照者0.23×10⁶根纤维/克干肺；（2）青石棉：患者3.56×10⁶根纤维/克干肺，对照者0.35×10⁶根纤维/克干肺；（3）总闪石：患者16.0×10⁶根纤维/克干肺，对照者0.77×10⁶根纤维/克干肺；（4）温石棉：患者3.76×10⁶根纤维/克干肺，对照者1.01×10⁶根纤维/克干肺。然而，考虑个体总石棉含量时，16例患者中有7例（44%）的含量低于对照者中记录的最高值。患者和对照者的肺纤维含量也显示存在非石棉纤维。患者的非石棉纤维几何平均值（87.3×10⁶根纤维/克干肺）显著高于对照者（33.8×10⁶根纤维/克干肺）（P<0.01）。两组中的主要非石棉纤维类型为硅酸铝。患者和对照者中非石棉纤维含量与总石棉纤维含量的平均比值分别为7.0和17.3。
结果主要与早期研究结果一致，但患者中温石棉和非石棉纤维以及闪石石棉的纤维含量均显著高于对照者。
