de Jong J P, Voerman J S, van der Sluijs-Gelling A J, Willemsen R, Ploemacher R E
Department of Hematology, Erasmus University, Rotterdam, The Netherlands.
Cell Tissue Res. 1994 Mar;275(3):567-76. doi: 10.1007/BF00318825.
We describe ER-HR3, a monoclonal antibody directed against bone marrow-derived haemopoietic reticulum cells. ER-HR3-positive cells have the electron-microscopic and enzyme-histochemical characteristics of macrophages. Additionally, they are able to phagocytoze. The ER-HR3 antigen is expressed by a majority of blood monocytes and is present on a subpopulation of resident macrophages in multiple organs. ER-HR3-positive cells are abundant in the bone marrow, the splenic red pulp, the mesenteric lymphoid paracortex and the interfollicular areas of the Peyer's patch. Few ER-HR3-positive cells have been observed in the thymic cortex and the connective tissues of the gastro-intestinal tract, the dermis and the renal medulla. Moreover, epidermal Langerhans cells express the antigen. No cross-reactivity with other cell types has been found. It is concluded that ER-HR3 has a unique distribution pattern distinct from other macrophage-specific antibodies.
我们描述了ER-HR3，一种针对骨髓来源的造血网状细胞的单克隆抗体。ER-HR3阳性细胞具有巨噬细胞的电子显微镜和酶组织化学特征。此外，它们能够进行吞噬作用。ER-HR3抗原在大多数血液单核细胞中表达，并且存在于多个器官中驻留巨噬细胞的一个亚群上。ER-HR3阳性细胞在骨髓、脾红髓、肠系膜淋巴副皮质以及派尔集合淋巴结的滤泡间区域丰富。在胸腺皮质以及胃肠道、真皮和肾髓质的结缔组织中观察到很少的ER-HR3阳性细胞。此外，表皮朗格汉斯细胞表达该抗原。未发现与其他细胞类型有交叉反应。得出的结论是，ER-HR3具有与其他巨噬细胞特异性抗体不同的独特分布模式。
