Imbriaco M, Cuocolo A, Pace L, Nicolai E, Nappi A, Celentano L, Palma G, Vosa C
Medical School, University Feolericolli, Italy.
Clin Nucl Med. 1994 Jan;19(1):28-32. doi: 10.1097/00003072-199401000-00009.
The authors evaluated the clinical applications of Tc-99m methoxy isobutyl isonitrile (MIBI) in the simultaneous assessment of ventricular function and myocardial perfusion in patients with congenital heart disease. Global ventricular function was assessed by first-pass ECG gated study. Myocardial perfusion was evaluated on images performed 1 hour after the injection of the tracer. Regional wall motion and systolic thickening were assessed by gated study acquired after the perfusion study. Two young patients were studied after a surgical Glenn procedure. The first patient, with a history of transposition of the great vessels and univentricular heart, had an ejection fraction of 44%. The left ventricle was dilated and the right ventricle was not appreciable. The septal and inferoapical regions showed reduced perfusion and reduced systolic thickening. The second patient, with a history of pulmonary atresia, septal defect and left ventricular hypoplasia, had a right ventricular ejection fraction of 37%. Regional wall motion, systolic thickening, and myocardial perfusion were normal. The right ventricle was hypertrophic and larger than the left ventricle. Thus, a single injection of Tc-99m MIBI allows noninvasive simultaneous assessment of global and regional ventricular function and myocardial perfusion in young patients with complicated congenital heart disease.
作者评估了锝-99m甲氧基异丁基异腈（MIBI）在先天性心脏病患者心室功能和心肌灌注同步评估中的临床应用。通过首次通过心电图门控研究评估整体心室功能。在注射示踪剂1小时后所采集的图像上评估心肌灌注。通过灌注研究后采集的门控研究评估节段性室壁运动和收缩期增厚情况。对两名接受了格林分流术的年轻患者进行了研究。第一名患者有大动脉转位和单心室心脏病史，射血分数为44%。左心室扩张，右心室不明显。室间隔和心尖下区域显示灌注减少和收缩期增厚减少。第二名患者有肺动脉闭锁、室间隔缺损和左心室发育不全病史，右心室射血分数为37%。节段性室壁运动、收缩期增厚和心肌灌注均正常。右心室肥厚且大于左心室。因此，单次注射锝-99m MIBI可对患有复杂先天性心脏病的年轻患者进行无创的整体和节段性心室功能及心肌灌注同步评估。
