左旋肉碱对耐力运动员肌肉中丙酮酸脱氢酶复合体及肉碱棕榈酰转移酶活性的影响。

Effects of L-carnitine on the pyruvate dehydrogenase complex and carnitine palmitoyl transferase activities in muscle of endurance athletes.

作者信息

Arenas J, Huertas R, Campos Y, Díaz A E, Villalón J M, Vilas E

机构信息

Centro de Investigación, Hospital 12 de Octubre, Madrid, Spain.

出版信息

FEBS Lett. 1994 Mar 14;341(1):91-3. doi: 10.1016/0014-5793(94)80246-7.

DOI:10.1016/0014-5793(94)80246-7

PMID:8137928

Abstract

The effects of L-carnitine on the pyruvate dehydrogenase (PDH) complex and carnitine palmitoyl transferase (CPT) were studied in muscle of 16 long-distance runners (LDR). These subjects received placebo or L-carnitine (2 g orally) during a 4-week period of training. Athletes receiving L-carnitine showed a dramatic increase (P < 0.001) in the PDH complex activities. By contrast, the levels of CPT, both 1 and 2, were unchanged. No significant changes were observed after placebo administration. We previously reported [Huertas R. et al., Biochem. Biophys. Res. Commun. 188 (1992) 102-107] that L-carnitine induces an increase in the activities of complexes I, III and IV of the respiratory chain in muscle of LDR. Taken together, our data suggest that the improvement in (maximal oxygen consumption) VO2max observed in LDR after L-carnitine administration is based on these biochemical findings.

摘要

在16名长跑运动员（LDR）的肌肉中研究了左旋肉碱对丙酮酸脱氢酶（PDH）复合物和肉碱棕榈酰转移酶（CPT）的影响。这些受试者在为期4周的训练期间接受了安慰剂或左旋肉碱（口服2克）。接受左旋肉碱的运动员的PDH复合物活性显著增加（P < 0.001）。相比之下，CPT-1和CPT-2的水平没有变化。给予安慰剂后未观察到显著变化。我们之前报道过[Huertas R.等人，生物化学与生物物理研究通讯188（1992）102 - 107]，左旋肉碱可诱导长跑运动员肌肉中呼吸链复合物I、III和IV的活性增加。综合来看，我们的数据表明，长跑运动员服用左旋肉碱后观察到的最大摄氧量（VO2max）的改善基于这些生化发现。