一种与胰腺激素PP（胰多肽）相同的猪肠道多肽。

A porcine gut polypeptide identical to the pancreatic hormone PP (pancreatic polypeptide).

作者信息

Chen Z W, Bergman T, Ostenson C G, Höög A, Näslund J, Norberg A, Carlquist M, Efendic S, Mutt V, Jörnvall H

机构信息

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

出版信息

FEBS Lett. 1994 Mar 21;341(2-3):239-43. doi: 10.1016/0014-5793(94)80464-8.

DOI:10.1016/0014-5793(94)80464-8

PMID:8137946

Abstract

A peptide hormone has been isolated from porcine intestine. Its primary structure was found to consist of 36 amino acid residues in a sequence identical to that of the porcine pancreatic polypeptide, previously not isolated from intestines or a tissue other than pancreas. The gut polypeptide significantly suppresses glucose-induced insulin secretion in vitro. Using an immunohistochemical technique, we also identified cells in the porcine gastrointestinal tract that were immunoreactive with pancreatic polypeptide. The immunoreactivity disappeared after absorption with the isolated gut polypeptide or synthetic human pancreatic polypeptide.

摘要

一种肽激素已从猪肠道中分离出来。发现其一级结构由36个氨基酸残基组成，序列与猪胰多肽相同，此前从未从肠道或胰腺以外的组织中分离出来。这种肠道多肽在体外能显著抑制葡萄糖诱导的胰岛素分泌。利用免疫组织化学技术，我们还在猪胃肠道中鉴定出了与胰多肽发生免疫反应的细胞。用分离出的肠道多肽或合成的人胰多肽吸收后，免疫反应消失。