Jayakumari N, Raghu K, Kumari V A, Balakrishnan K G, Iyer K S
Department of Biochemistry & Cardiology, SCTIMS&T, Trivandrum.
Indian Heart J. 1993 Jul-Aug;45(4):265-8.
The distribution of HDL-C and its subclasses HDL3-C and HDL2-C and other serum lipids was studied in patients with coronary atherosclerotic heart disease grouped as young males (group 1) and older males (group 2) along with age matched controls. All the patients had significantly higher levels of serum cholesterol, triglycerides, LDL-C and VLDL-C and lower levels of HDL-C. The analysis of HDL - subclasses clearly demonstrated that the low levels of HDL-C was due to the significant decrease of cholesterol in both HDL3 (group 1: 32%; group 2: 30%) and HDL2 subclasses (group 1: 55%; group 2: 48%) compared to the respective control values. Further it has also been observed that this low level of HDL-C is a characteristic feature of patients irrespective of whether the levels of serum cholesterol and triglycerides are high or normal. Although both the HDL subclasses were decreased, the percentage of reduction of cholesterol was greater in the HDL2 than in HDL3 subclass. In addition, the levels of cholesterol either in HDL or any of its subclasses, HDL3 and HDL2 did not show any change in relation to the extent of coronary disease which was assessed by coronary angiography. This study confirms the inverse relation of HDL-C with coronary atherosclerosis and also indicates that, of all the lipid parameters examined, only HDL-C, particularly its subclass HDL2-C, shows independent inverse relation to the incidence of coronary atherosclerotic artery disease in men.
在将患有冠状动脉粥样硬化性心脏病的患者分为年轻男性组（第1组）和老年男性组（第2组）以及年龄匹配的对照组中，研究了高密度脂蛋白胆固醇（HDL-C）及其亚类高密度脂蛋白3胆固醇（HDL3-C）和高密度脂蛋白2胆固醇（HDL2-C）以及其他血脂的分布情况。所有患者的血清胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-C）和极低密度脂蛋白胆固醇（VLDL-C）水平均显著升高，而高密度脂蛋白胆固醇水平降低。对高密度脂蛋白亚类的分析清楚地表明，与各自的对照值相比，高密度脂蛋白胆固醇水平低是由于高密度脂蛋白3（第1组：32%；第2组：30%）和高密度脂蛋白2亚类（第1组：55%；第2组：48%）中的胆固醇显著降低所致。此外，还观察到，无论血清胆固醇和甘油三酯水平是高还是正常，高密度脂蛋白胆固醇水平低都是患者的一个特征性表现。虽然两个高密度脂蛋白亚类均降低，但高密度脂蛋白2中胆固醇降低的百分比大于高密度脂蛋白3亚类。此外，通过冠状动脉造影评估的冠状动脉疾病程度与高密度脂蛋白或其任何亚类（高密度脂蛋白3和高密度脂蛋白2）中的胆固醇水平均未显示任何变化。本研究证实了高密度脂蛋白胆固醇与冠状动脉粥样硬化的负相关关系，并且还表明，在所有检测的血脂参数中，只有高密度脂蛋白胆固醇，特别是其亚类高密度脂蛋白2胆固醇，与男性冠状动脉粥样硬化性动脉疾病的发生率呈独立负相关。
