Ghadirian A M, Dubrovsky B
Department of Psychiatry, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada.
Int J Neurosci. 1993 Oct;72(3-4):245-50. doi: 10.3109/00207459309024112.
In a longitudinal CNV study of bipolar illness we followed the evolution of this illness in six bipolar patients by recording their CNV and mood changes as well as their psychopharmacological treatment for a period of 8 months. The longitudinal CNV recordings of these patients did not show changes corresponding to their mood variations. The most salient result emerging from this study was the consistency in the patterns of the records in different patients in spite of variations in their clinical state and medications. We believe that these electrophysiological parameters cannot be used as markers of the mental state in bipolar patients nor do they reflect specific drug effect. These findings are congruent with available data which do not support a linear relationship between a complex psychological process such as manic depressive illness and a single physical dimension of brain activity. Further studies are warranted for a deeper understanding of this phenomenon.
在一项关于双相情感障碍的纵向CNV研究中，我们通过记录6名双相情感障碍患者的CNV、情绪变化以及他们的心理药物治疗情况，对这一疾病的发展进行了为期8个月的跟踪。这些患者的纵向CNV记录并未显示出与他们情绪变化相对应的改变。该研究最显著的结果是，尽管不同患者的临床状态和用药情况存在差异，但他们记录模式具有一致性。我们认为，这些电生理参数既不能用作双相情感障碍患者精神状态的标志物，也不能反映特定药物的效果。这些发现与现有数据一致，现有数据不支持诸如躁郁症这样的复杂心理过程与大脑活动的单一物理维度之间存在线性关系。有必要进行进一步研究以更深入地理解这一现象。
