Richardson G A, Day N L
Program in Epidemiology, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213.
J Am Acad Child Adolesc Psychiatry. 1994 Jan;33(1):28-34. doi: 10.1097/00004583-199401000-00005.
The primary purpose of this study is to investigate the impact of prenatal cocaine exposure, while controlling for other factors that influence infant outcome.
These preliminary data are from an ongoing prospective study of prenatal cocaine and/or crack exposure. Detailed information is collected about the use of cocaine, crack, alcohol, tobacco, marijuana, and other drugs during each trimester of pregnancy.
Women who use cocaine and/or crack during pregnancy differ from those who do not. The women who use cocaine are older, more likely to be black, and less likely to be married. They also use more tobacco, alcohol, and marijuana during pregnancy than do nonusers of cocaine. When these differences between the exposure groups are controlled, preliminary analyses indicate there is no significant effect of prenatal cocaine use on infant growth and morphology.
Future research needs to address the effects of prenatal cocaine and/or crack exposure on central nervous system development and on the long-term development of exposed offspring.
本研究的主要目的是在控制其他影响婴儿结局的因素的同时,调查产前接触可卡因的影响。
这些初步数据来自一项正在进行的关于产前接触可卡因和/或强效纯可卡因的前瞻性研究。收集了关于孕期每个阶段使用可卡因、强效纯可卡因、酒精、烟草、大麻和其他药物的详细信息。
孕期使用可卡因和/或强效纯可卡因的女性与未使用者不同。使用可卡因的女性年龄更大,更有可能是黑人,结婚的可能性更小。她们在孕期使用的烟草、酒精和大麻也比不使用可卡因的女性更多。当控制暴露组之间的这些差异时,初步分析表明产前使用可卡因对婴儿生长和形态没有显著影响。
未来的研究需要探讨产前接触可卡因和/或强效纯可卡因对中枢神经系统发育以及对暴露后代长期发育的影响。