[Structural transitions of the Torpedo cholinergic receptor in its membrane state as demonstrated by a fluorescent local anesthetic: quinacrine].
作者信息
Grünhagen H, Changeux J P
出版信息
C R Acad Hebd Seances Acad Sci D. 1975 Oct 6;281(14):1047-50.
PMID:813874
Abstract
Differential fluorescence emissions of receptor-rich membrane fragments prepared from Torpedo marmorata electric organ and labelled by a fluorescent local anesthetic quinacrine are obtained by energy transfer. Addition of a cholinergic effector causes two classes of structural transitions, fast and slow, which are related to the agonist or antagonist character of the ligand.
摘要
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[Structural transitions of the Torpedo cholinergic receptor in its membrane state as demonstrated by a fluorescent local anesthetic: quinacrine].
C R Acad Hebd Seances Acad Sci D. 1975 Oct 6;281(14):1047-50.
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Fast kinetic studies on the interaction of cholinergic agonists with the membrane-bound acetylcholine receptor from Torpedo marmorata as revealed by quinacrine fluorescence.通过喹吖因荧光揭示的关于胆碱能激动剂与电鳐膜结合型乙酰胆碱受体相互作用的快速动力学研究。
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[Purification of a protein binding quinacrine and histrionicotoxin from membrane fragments rich in cholinergic receptors in Torpedo marmorata].[从电鳐富含胆碱能受体的膜片段中纯化结合喹吖因和组氨酰毒的蛋白质]
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6
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. V. Qualitative correlation between pharmacological effects and equilibration processes of the cholinergic receptor protein as revealed by the structural probe quinacrine.
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[Rapid changes in the intensity of fluorescence observed in the presence of cholinergic agonists with Torpedo marmorata membrane fragments rich in cholinergic receptors and labelled with quinacrine].[在富含胆碱能受体并用喹吖因标记的电鳐膜片段存在下，胆碱能激动剂存在时观察到的荧光强度的快速变化]
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Acetylcholine receptor. Binding properties and ion permeability response after covalent attachment of the local anaesthetic quinacrine.乙酰胆碱受体。局部麻醉药喹吖因共价结合后的结合特性及离子通透性反应。
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9
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. III. Pharmocological desensitization in vitro of the receptor-rich membrane fragments by cholinergic agonists.用斑纹电鳐电器官研究乙酰胆碱的电生成作用。III. 胆碱能激动剂对富含受体的膜片段的体外药理学脱敏作用。
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10
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. II. The permeability response of the receptor-rich membrane fragments to cholinergic agonists in vitro.用斑纹电鳐电器官研究乙酰胆碱的生电作用。II. 富含受体的膜片段在体外对胆碱能激动剂的通透性反应。
J Mol Biol. 1976 Sep 25;106(3):469-83. doi: 10.1016/0022-2836(76)90247-3.
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