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Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. IV. Quinacrine: a fluorescent probe for the conformational transitions of the cholinergic receptor protein in its membrane-bound state.

作者信息

Grünhagen H H, Changeux J P

出版信息

J Mol Biol. 1976 Sep 25;106(3):497-516. doi: 10.1016/0022-2836(76)90249-7.

DOI:10.1016/0022-2836(76)90249-7
PMID:978733
Abstract
摘要

相似文献

1
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. IV. Quinacrine: a fluorescent probe for the conformational transitions of the cholinergic receptor protein in its membrane-bound state.
J Mol Biol. 1976 Sep 25;106(3):497-516. doi: 10.1016/0022-2836(76)90249-7.
2
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. I. Pharmacological properties of the electroplaque.用斑纹电鳐电器官对乙酰胆碱的电生成作用的研究。I. 电板的药理学特性。
J Mol Biol. 1976 Sep 25;106(3):457-67. doi: 10.1016/0022-2836(76)90246-1.
3
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. II. The permeability response of the receptor-rich membrane fragments to cholinergic agonists in vitro.用斑纹电鳐电器官研究乙酰胆碱的生电作用。II. 富含受体的膜片段在体外对胆碱能激动剂的通透性反应。
J Mol Biol. 1976 Sep 25;106(3):469-83. doi: 10.1016/0022-2836(76)90247-3.
4
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. V. Qualitative correlation between pharmacological effects and equilibration processes of the cholinergic receptor protein as revealed by the structural probe quinacrine.
J Mol Biol. 1976 Sep 25;106(3):517-35. doi: 10.1016/0022-2836(76)90250-3.
5
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. III. Pharmocological desensitization in vitro of the receptor-rich membrane fragments by cholinergic agonists.用斑纹电鳐电器官研究乙酰胆碱的电生成作用。III. 胆碱能激动剂对富含受体的膜片段的体外药理学脱敏作用。
J Mol Biol. 1976 Sep 25;106(3):485-96. doi: 10.1016/0022-2836(76)90248-5.
6
[Structural transitions of the Torpedo cholinergic receptor in its membrane state as demonstrated by a fluorescent local anesthetic: quinacrine].
C R Acad Hebd Seances Acad Sci D. 1975 Oct 6;281(14):1047-50.
7
[Rapid changes in the intensity of fluorescence observed in the presence of cholinergic agonists with Torpedo marmorata membrane fragments rich in cholinergic receptors and labelled with quinacrine].[在富含胆碱能受体并用喹吖因标记的电鳐膜片段存在下，胆碱能激动剂存在时观察到的荧光强度的快速变化]
C R Acad Hebd Seances Acad Sci D. 1976 Oct 18;283(9):1105-8.
8
Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. II. Effect of cholinergic agonists and antagonists on the binding of the tritiated alpha-neurotoxin.眼镜蛇（3H）α-毒素与电鳗和电鳐电器官膜片段的结合。II. 胆碱能激动剂和拮抗剂对氚化α-神经毒素结合的影响。
Mol Pharmacol. 1974 Jan;10(1):15-34.
9
Fast kinetic studies on the interaction of cholinergic agonists with the membrane-bound acetylcholine receptor from Torpedo marmorata as revealed by quinacrine fluorescence.通过喹吖因荧光揭示的关于胆碱能激动剂与电鳐膜结合型乙酰胆碱受体相互作用的快速动力学研究。
Eur J Biochem. 1977 Oct 17;80(1):225-42. doi: 10.1111/j.1432-1033.1977.tb11875.x.
10
Covalent labeling of functional states of the acetylcholine receptor. Effects of antagonists on the receptor conformation.乙酰胆碱受体功能状态的共价标记。拮抗剂对受体构象的影响。
Eur J Biochem. 1985 Mar 15;147(3):483-7. doi: 10.1111/j.0014-2956.1985.00483.x.

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The concept of allosteric interaction and its consequences for the chemistry of the brain.变构相互作用的概念及其对大脑化学的影响。
J Biol Chem. 2013 Sep 20;288(38):26969-26986. doi: 10.1074/jbc.X113.503375. Epub 2013 Jul 22.
2
The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamily.烟碱型乙酰胆碱受体：五聚体配体门控离子通道超家族的奠基人。
J Biol Chem. 2012 Nov 23;287(48):40207-15. doi: 10.1074/jbc.R112.407668. Epub 2012 Oct 4.
3
Mepacrine-induced inhibition of the inward current mediated by 5-HT3 receptors in rat nodose ganglion neurones.
米帕林对大鼠结状神经节神经元中由5-羟色胺3受体介导的内向电流的抑制作用。
Br J Pharmacol. 1994 Jul;112(3):745-8. doi: 10.1111/j.1476-5381.1994.tb13141.x.
4
Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels.烟碱型乙酰胆碱受体的功能结构：配体门控离子通道的一个原型。
J Membr Biol. 1993 Nov;136(2):97-112. doi: 10.1007/BF02505755.
5
Activation and desensitization of Torpedo acetylcholine receptor: evidence for separate binding sites.电鳐乙酰胆碱受体的激活与脱敏：不同结合位点的证据。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6757-61. doi: 10.1073/pnas.79.22.6757.
6
Effects of amphipathic drugs on L'[3H]glutamate binding to synaptic membranes and the purified binding protein.两亲性药物对L'[3H]谷氨酸与突触膜及纯化结合蛋白结合的影响。
Neurochem Res. 1984 Jan;9(1):29-44. doi: 10.1007/BF00967657.
7
End-plate channel opening and the kinetics of quinacrine (mepacrine) block.终板通道开放与喹吖因（米帕林）阻断的动力学
J Physiol. 1980 Sep;306:283-306. doi: 10.1113/jphysiol.1980.sp013397.
8
Is an acetylcholine transport system responsible for nonquantal release of acetylcholine at the rodent myoneural junction?乙酰胆碱转运系统是否负责啮齿动物肌神经接头处乙酰胆碱的非量子释放？
Proc Natl Acad Sci U S A. 1985 May;82(10):3514-8. doi: 10.1073/pnas.82.10.3514.
9
Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.乙酰胆碱受体非竞争性阻滞剂的高亲和力结合位点结构：δ亚基的丝氨酸-262被[3H]氯丙嗪标记。
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2719-23. doi: 10.1073/pnas.83.8.2719.
10
Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators.烟碱型乙酰胆碱受体的脱敏：分子机制及调节剂的作用
Cell Mol Neurobiol. 1989 Jun;9(2):141-78. doi: 10.1007/BF00713026.