Sakamaki H, Takamoto S, Shibata H
Bone Marrow Transplantation Team, Tokyo Metropolitan Komagome Hospital.
Rinsho Ketsueki. 1994 Jan;35(1):29-35.
Seventy-four responses were received from a questionnaire which had been mailed to 91 bone marrow transplantation institutes throughout Japan to assess the activity of bone marrow transplantation and complications in bone marrow donors. A total of 2329 bone marrow harvests, performed from 1688 adult donors and 641 child donors for allogeneic or syngeneic transplantation up to August 1992, were available for study. Analyses of the responses showed slight diversity regarding the marrow harvesting preparation and methods of the different bone marrow programs. The resulting perioperative complications were principally caused by anesthesia: 73 episodes of hypotension including one death 18 months later, seven of arrhythmia, one of respiratory arrest, three of mental confusion, one of asthma, one of malignant hyperthermia, one tooth injury and one broken aspiration needle. The postoperative complications were chiefly caused by marrow aspiration per se: 731 episodes of transient fever, 26 of long-lasting pain or discomfort, 10 episodes of liver dysfunction including two cases of non-A, non-B hepatitis, four cases of infection, one episode of hypotension, one of dysuria and one case of keloid formation. The study further revealed that the frequency of complications was lower in child donors than in adult donors.
通过向日本全国91家骨髓移植机构邮寄调查问卷，以评估骨髓移植活动及骨髓供者的并发症，共收到74份回复。截至1992年8月，共有2329例骨髓采集，这些采集来自1688名成年供者和641名儿童供者，用于同种异体或同基因移植，可供研究。对回复的分析显示，不同骨髓项目在骨髓采集准备和方法上存在轻微差异。围手术期并发症主要由麻醉引起：73例低血压事件，其中1例在18个月后死亡，7例心律失常，1例呼吸骤停，3例精神错乱，1例哮喘，1例恶性高热，1例牙齿损伤和1例穿刺针折断。术后并发症主要由骨髓穿刺本身引起：731例短暂发热，26例持续疼痛或不适，10例肝功能障碍，其中2例为非甲非乙型肝炎，4例感染，1例低血压，1例排尿困难和1例瘢痕疙瘩形成。该研究进一步表明，儿童供者的并发症发生率低于成年供者。
