舒必利对人催乳素分泌的刺激作用。

Stimulation of human prolactin secretion by sulpiride.

作者信息

Kato Y, Ohgo S, Chihara K, Imura H

出版信息

Endocrinol Jpn. 1975 Oct;22(5):457-60. doi: 10.1507/endocrj1954.22.457.

DOI:10.1507/endocrj1954.22.457

Abstract

Intramuscular injection of 100 mg of sulpiride significantly raised plasma human prolactin (hPRL) levels in all of 7 normal subjects examined. The mean (+SE) peak value was 78.0 +/- 16.6 ng/ml, which was observed 30 min after the injection. Daily administration of sulpiride (50 mg tid po) raised plasma hPRL levels in all 7 patients with peptic ulcer, with peak values obtained within 2 weeks. Lactation occurred in 2 of these patients. It is concluded that sulpiride stimulates hPRL secretion in man.

摘要

对7名正常受试者进行肌内注射100毫克舒必利后，所有人的血浆人催乳素（hPRL）水平均显著升高。平均（±标准误）峰值为78.0±16.6纳克/毫升，在注射后30分钟观察到。对7名消化性溃疡患者每日给予舒必利（50毫克，口服，每日三次），所有患者的血浆hPRL水平均升高，在2周内达到峰值。其中2名患者出现泌乳。结论是舒必利可刺激人体hPRL分泌。