Guerrero R O, Robledo I
Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, San Juan 00936-5067.
P R Health Sci J. 1993 Dec;12(4):259-62.
A total of 49 endemic plants of Puerto Rico were evaluated for their toxicological and antibacterial activities. The toxicological analysis was conducted with brine shrimp (Artemia salina Leach) lethality bioassay and the antibacterial screening was carried out by means of the agar diffusion test. In the toxicological bioassay, six plant extracts showed LC-50 values below 200 g/ml., indicating the potential presence of bioactive compounds. In the antibacterial screening, over 80% of the plant extracts displayed activity against gram positive bacteria, whereas only 6% of the extracts inhibited the growth of the gram negative bacteria.
对波多黎各的49种本土植物进行了毒理学和抗菌活性评估。毒理学分析采用卤虫（Artemia salina Leach）致死率生物测定法进行，抗菌筛选通过琼脂扩散试验进行。在毒理学生物测定中，六种植物提取物的LC-50值低于200微克/毫升，表明可能存在生物活性化合物。在抗菌筛选中，超过80%的植物提取物对革兰氏阳性菌有活性，而只有6%的提取物能抑制革兰氏阴性菌的生长。
