Lee T J, Carney C N, Lapis J L, Higgins T, Fallon H J
Gastroenterology. 1976 Mar;70(3):422-4.
A patient with post-traumatic seizure disorder developed lymphadenopathy, exfoliative dermatitis, and hepatic failure while on diphenylhydantoin therapy and died in hepatic coma. Autopsy disclosed massive hepatic necrosis. The clinical and pathological pictures are similar to the six previously reported cases of diphenylhydantoin-induced hepatic necrosis, with the exception of the time of onset of hepatic failure, which is explained. The cause of such hepatotoxicity is unknown, although hypersensitivity is postulated. It appears that studies of liver function in patients receiving diphenylhydantion are indicated to assess the true indicence of hepatocellular injury.
一名患有创伤后癫痫障碍的患者在接受苯妥英治疗时出现了淋巴结病、剥脱性皮炎和肝衰竭，并死于肝昏迷。尸检显示有大量肝坏死。临床和病理表现与先前报道的6例苯妥英诱导的肝坏死病例相似，只是肝衰竭的发病时间有所不同，对此作出了解释。虽然推测是超敏反应，但这种肝毒性的原因尚不清楚。似乎有必要对接受苯妥英治疗的患者进行肝功能研究，以评估肝细胞损伤的真实发生率。
