Brooks C D, Karl K J, Francom S F
Upjohn Research Clinics, Kalamazoo.
Rhinology. 1993 Dec;31(4):165-8.
Acute nasal allergen challenge produces airway obstruction which varies in amount and timing with the allergen dose delivered. To see whether different mechanisms might contribute variably to mucosal swelling with different amounts of allergen, we challenged sensitive volunteers with threshold and 10-times threshold allergen doses, with and without topical vasoconstrictor pre-treatment. The vasoconstrictor effectively eliminated obstruction at both allergen dose levels, suggesting that acute vascular changes were responsible for all the measurable obstruction seen with acute allergen provocation. Alpha-adrenergic vasoconstrictor pre-treatment was associated with increased weight of secretion and numbers of sneezes.
急性鼻过敏原激发试验会导致气道阻塞，其程度和发生时间会因所给予的过敏原剂量不同而有所变化。为了探究不同机制是否会因过敏原量的不同而对黏膜肿胀产生不同程度的影响，我们对敏感志愿者进行了阈值剂量和10倍阈值剂量的过敏原激发试验，试验中有的进行了局部血管收缩剂预处理，有的未进行。血管收缩剂在两种过敏原剂量水平下均有效消除了阻塞，这表明急性血管变化是急性过敏原激发试验中所有可测量阻塞的原因。α-肾上腺素能血管收缩剂预处理与分泌物重量增加和喷嚏次数增多有关。
