Zhong Z, Wen Z, Darnell J E
Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021.
Science. 1994 Apr 1;264(5155):95-8. doi: 10.1126/science.8140422.
The STAT family of proteins carries out a dual function: signal transduction and activation of transcription. A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). It is likely that this phosphoprotein forms homodimers as well as heterodimers with the first described member of the STAT family, Stat91 (renamed Stat1 alpha), which is activated by the IFNs and EGF. Differential activation of different STAT proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface.
信号转导和转录激活因子（STAT）蛋白家族具有双重功能：信号转导和转录激活。一个新的家族成员Stat3，作为一种DNA结合蛋白，在受到表皮生长因子（EGF）和白细胞介素-6（IL-6）刺激时，通过酪氨酸磷酸化而被激活，但对干扰素γ（IFN-γ）无反应。这种磷蛋白很可能与STAT家族的首个成员Stat91（重新命名为Stat1α）形成同二聚体以及异二聚体，Stat91可被干扰素和EGF激活。不同的STAT蛋白对不同配体的差异激活，应有助于解释细胞表面核信号传导的特异性。
