Steingrímsson O, Olafsson J H, Thórarinsson H, Ryan R W, Johnson R B, Tilton R C
Department of Microbiology, University of Iceland, Reykjavik.
Sex Transm Dis. 1994 Jan-Feb;21(1):43-6. doi: 10.1097/00007435-199401000-00009.
Single dose regimens have advantages in the treatment of STD. Azithromycin has unique pharmacokinetics that may make single dose regimens feasible. Treatment with a single 1 g dose of azithromycin was compared to 100 mg doxycycline twice daily for seven days.
This was a randomized third-party blinded study on 183 male patients, 176 of whom could be evaluated for efficacy.
Chlamydia trachomatis was cultured from 148 patients, 79 receiving azithromycin and 69 receiving doxycycline. Six patients receiving azithromycin had positive cultures on follow-up, four were known to have had sexual intercourse with infected partners. Fifty-one patients had gonorrhea; 28 were treated with azithromycin and 23 with doxycycline. Neisseria gonorrhoeae was eradicated from all patients except one receiving azithromycin. He denied sexual exposure during follow-up. Sixty patients were infected with Ureaplasma urealyticum, 35 were treated with azithromycin and 25 with doxycycline. Five patients in each group had positive cultures on follow up. Three patients receiving azithromycin and two receiving doxycycline were known to have had sexual exposure during follow-up.
A single dose of azithromycin showed similar effectiveness as a 7-day regimen of doxycycline.
单剂量疗法在性传播疾病（STD）治疗中具有优势。阿奇霉素具有独特的药代动力学特性，这可能使单剂量疗法成为可行的治疗方案。将单次服用1克阿奇霉素的治疗方案与每日两次服用100毫克强力霉素，连续服用7天的治疗方案进行了比较。
这是一项针对183名男性患者的随机第三方盲法研究，其中176名患者可进行疗效评估。
从148名患者中培养出沙眼衣原体，79名接受阿奇霉素治疗，69名接受强力霉素治疗。6名接受阿奇霉素治疗的患者在随访时培养结果呈阳性，其中4名已知与感染伴侣有过性行为。51名患者患有淋病；28名接受阿奇霉素治疗，23名接受强力霉素治疗。除一名接受阿奇霉素治疗的患者外，所有患者的淋病奈瑟菌均被根除。该患者在随访期间否认有性接触。60名患者感染了解脲脲原体，35名接受阿奇霉素治疗，25名接受强力霉素治疗。每组各有5名患者在随访时培养结果呈阳性。已知3名接受阿奇霉素治疗的患者和2名接受强力霉素治疗的患者在随访期间有性接触。
单次服用阿奇霉素的疗效与7天疗程的强力霉素相似。
