Arno J N, Katz B P, McBride R, Carty G A, Batteiger B E, Caine V A, Jones R B
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5124.
Sex Transm Dis. 1994 Jan-Feb;21(1):47-52. doi: 10.1097/00007435-199401000-00010.
The prevalence of chlamydial infection decreases with age possibly in part because of increasing immunity.
To determine whether increased age is an independent predictor of decreased chlamydial infection and whether chlamydia-specific antibody titer and blastogenesis increase with age.
Data from all patients cultured for Chlamydia trachomatis between January 1984 and August 1989 were examined and multiple logistic regression models were used to identify the independent predictors of culture positivity. Antichlamydial antibody titer and chlamydia-specific blastogenesis were examined for a subset of patients for correlation with age.
Young age was found to be predictive of chlamydial infection independent of all factors examined in men and women. Antibody titers had no relation to age (n = 245) whereas the level of blastogenesis correlated only weakly with age (n = 155).
Assays of systemic immunity do not reflect the protection from chlamydial infection associated with age.
衣原体感染的患病率随年龄增长而降低，这可能部分归因于免疫力的增强。
确定年龄增长是否是衣原体感染减少的独立预测因素，以及衣原体特异性抗体滴度和淋巴细胞增殖是否随年龄增长而增加。
检查了1984年1月至1989年8月间所有培养沙眼衣原体的患者的数据，并使用多元逻辑回归模型来确定培养阳性的独立预测因素。对一部分患者的抗衣原体抗体滴度和衣原体特异性淋巴细胞增殖进行了检查，以分析其与年龄的相关性。
发现年轻是衣原体感染的预测因素，与男性和女性所检查的所有因素无关。抗体滴度与年龄无关（n = 245），而淋巴细胞增殖水平与年龄的相关性较弱（n = 155）。
全身免疫测定不能反映与年龄相关的对衣原体感染的保护作用。
