Fazioli F, Blasi F
Dipartimento di Biologica e Tecnologica, San Raffaele Scientific Institute, Milano, Italy.
Trends Pharmacol Sci. 1994 Jan;15(1):25-9. doi: 10.1016/0165-6147(94)90130-9.
Urokinase-type plasminogen activator (uPA) and its receptor are instrumental in cell invasion and metastasis; their high levels of expression in human tumours correlates with a high risk of recurrence. uPA has a pleiotropic effect on cell migration and spreading in vivo and in vitro through the activation of plasminogen or other protein factors at the cell surface or in the extracellular matrix. Three specific inhibitors, with different tissue-specificities and regulatory properties, modulate cell-surface exposure of uPA activity. Overall, uPA is at the centre of a complex system affecting cell movement and invasiveness, and inhibition of uPA is now a goal of anti-metastatic therapy. The role of uPA and its inhibition are discussed in this review by Francesca Fazioli and Francesco Blasi.
尿激酶型纤溶酶原激活剂（uPA）及其受体在细胞侵袭和转移中起重要作用；它们在人类肿瘤中的高表达与高复发风险相关。uPA通过在细胞表面或细胞外基质中激活纤溶酶原或其他蛋白质因子，在体内和体外对细胞迁移和扩散具有多效性作用。三种具有不同组织特异性和调节特性的特异性抑制剂可调节uPA活性在细胞表面的暴露。总体而言，uPA处于影响细胞运动和侵袭性的复杂系统的中心，抑制uPA现在是抗转移治疗的目标。Francesca Fazioli和Francesco Blasi在本综述中讨论了uPA的作用及其抑制作用。
