Sivaramakrishnan K, Alexander P J, Saharsarnamam N
Department of Psychiatry, Medical College, Calicut, India.
Acta Psychiatr Scand. 1994 Jan;89(1):59-61. doi: 10.1111/j.1600-0447.1994.tb01486.x.
This study investigated the relationship between mitral valve prolapse (MVP) and panic disorder (PD), by comparing the prevalence of PD in 33 patients with MVP and 27 patients with haemodynamically insignificant atrial septal defect or patent ductus arteriosus. MVP was diagnosed using standard echocardiographic criteria and the presence of mental disorder was assessed blindly with the help of the Schedule for Affective Disorders and Schizophrenia. DSM-III criteria were used to diagnose PD. The two groups did not differ in age and sex; 12.1% of MVP patients and 3.7% of cardiac controls had PD (NS). Although the prevalence of PD in our sample of MVP patients was considerably higher than the prevalence of PD in the general population, this need not necessarily indicate a causal relationship between MVP and PD and may be due to studying a hospital-based sample. The absence of any significant difference in prevalence of PD between MVP patients and a carefully selected cardiac control group drawn from the same setting argues against any special relationship between PD and MVP.
本研究通过比较33例二尖瓣脱垂（MVP）患者和27例血流动力学无显著意义的房间隔缺损或动脉导管未闭患者中惊恐障碍（PD）的患病率，探讨了MVP与PD之间的关系。MVP采用标准超声心动图标准进行诊断，借助情感障碍和精神分裂症检查表对精神障碍的存在进行盲法评估。采用《精神疾病诊断与统计手册》第三版（DSM-III）标准诊断PD。两组在年龄和性别上无差异；12.1%的MVP患者和3.7%的心脏对照者患有PD（无显著性差异）。尽管我们样本中MVP患者的PD患病率显著高于一般人群中的PD患病率，但这不一定表明MVP与PD之间存在因果关系，可能是由于研究的是基于医院的样本。MVP患者与从同一环境中精心挑选的心脏对照组之间PD患病率无任何显著差异，这反驳了PD与MVP之间存在任何特殊关系的观点。
