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细胞表面免疫球蛋白。十六。小鼠IgM和IgD样分子的多肽链结构。

Cell surface immunoglobulin. XVI. Polypeptide chain structure of mouse IgM and IgD-like molecule.

作者信息

Melcher U, Uhr J W

出版信息

J Immunol. 1976 Feb;116(2):409-15.

PMID:814162
Abstract

125I-membrane IgM, 125I-membrane IgD-like molecules, and their constituent chains from iodinated murine splenocytes were characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis. The apparent m.w. of the heavy chains decreased as the acrylamide concentration was raised. The membrane mu-chain had a slower mobility than did mu-chain from secreted IgM. Unreduced IgM and IgD-like molecules had mobilities consistent with an H2L2 structure. Intact IgD-like molecules were replaced after overnight dialysis by molecules with the properties of HL. Unreduced surface IgM had a slower mobility than that of monomeric IgM obtained by partial reduction of secreted IgM.

摘要

通过十二烷基硫酸钠聚丙烯酰胺凝胶电泳对来自碘化小鼠脾细胞的125I-膜IgM、125I-膜IgD样分子及其组成链进行了表征。随着丙烯酰胺浓度的升高，重链的表观分子量降低。膜μ链的迁移率比分泌型IgM的μ链慢。未还原的IgM和IgD样分子的迁移率与H2L2结构一致。过夜透析后，完整的IgD样分子被具有HL特性的分子所取代。未还原的表面IgM的迁移率比通过部分还原分泌型IgM获得的单体IgM慢。

相似文献

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J Immunol. 1976 Feb;116(2):409-15.
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引用本文的文献

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Possible palindromes in immunoglobulin heavy-chain genes: Their role in membrane attachment.可能存在于免疫球蛋白重链基因中的回文序列：它们在膜附着中的作用。
Immunogenetics. 1978 Dec;7(1):1-12. doi: 10.1007/BF01843981.
2
In Vitro Synthesis of a Precursor to the Methionine-rich Polypeptide of the Zein Fraction of Corn.玉米醇溶蛋白中甲硫氨酸丰富多肽前体的体外合成。
Plant Physiol. 1979 Feb;63(2):354-8. doi: 10.1104/pp.63.2.354.
3
Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line.在一个杂交小鼠细胞系中，从半抗原特异性免疫球蛋白M分泌转换为免疫球蛋白D分泌。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1138-42. doi: 10.1073/pnas.78.2.1138.
4
Differential regulation of membrane and secretory mu chain synthesis in human beta cell lines. Regulation of membrane mu or secreted mu.人β细胞系中膜结合型和分泌型μ链合成的差异调节。膜结合型μ链或分泌型μ链的调节。
J Exp Med. 1982 Dec 1;156(6):1622-34. doi: 10.1084/jem.156.6.1622.
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Biosynthesis and structure of membrane and secretory immunoglobulins.膜免疫球蛋白和分泌型免疫球蛋白的生物合成与结构
Mol Cell Biochem. 1982 Aug 20;47(1):11-22. doi: 10.1007/BF00241561.
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Biogenesis of membrane-bound and secreted immunoglobulins: two primary translation products of the human delta chain, differentially N-glycosylated to four discrete forms in vivo and in vitro.膜结合型和分泌型免疫球蛋白的生物合成：人δ链的两种主要翻译产物，在体内和体外被差异N-糖基化形成四种不同形式。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5127-31. doi: 10.1073/pnas.78.8.5127.
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