Cherniakova I V, Zhukov V N, Osipov S A, Shadiev A Sh, Skovpen' T V
Eksp Klin Farmakol. 1994 Jan-Feb;57(1):13-5.
Experimental studies were undertaken to examine azacaine used in mice during conduction anesthesia and in rabbits during epidural anesthesia in 0.75, 2 and 0.75, 1% solutions, respectively. It was found that azacaine in the above doses is 1.5-3.5-fold superior to 2% solutions of lidocaine (xycaine) and trimecaine (mesocaine) in their effect duration. Histological studies of the rabbit spinal cord after epidural azacaine administration revealed no significant changes in brain tissues.
进行了实验研究，分别在传导麻醉期间给小鼠使用阿扎卡因，以及在硬膜外麻醉期间给兔子使用0.75%、2%和0.75%、1%溶液的阿扎卡因。结果发现，上述剂量的阿扎卡因在作用持续时间上比2%利多卡因（赛罗卡因）溶液和三甲卡因（美索卡因）溶液强1.5至3.5倍。对硬膜外注射阿扎卡因后的兔子脊髓进行组织学研究，结果显示脑组织无明显变化。
