非经典的Ib类主要组织相容性复合体（MHC）分子会将细菌抗原呈递给T细胞吗？
Do nonclassical, class Ib MHC molecules present bacterial antigens to T cells?
作者信息
Pamer E G, Bevan M J, Lindahl K F
机构信息
Infectious Disease Section, Yale University School of Medicine, New Haven, CT 06510-8056.
出版信息
Trends Microbiol. 1993 Apr;1(1):35-8. doi: 10.1016/0966-842x(93)90023-k.
PMID:8143114
Abstract
Immune responses to bacterial antigens that appear unrestricted by the MHC may involve oligomorphic MHC class Ib molecules. One example is H-2M3, which binds N-formylated peptides and presents a Listeria peptide to cytotoxic T cells from infected mice. Lack of polymorphism makes these molecules a promising target for peptide vaccines.
摘要
对不受主要组织相容性复合体（MHC）限制的细菌抗原的免疫反应可能涉及寡态性MHC Ib类分子。一个例子是H-2M3，它结合N-甲酰化肽，并将李斯特菌肽呈递给受感染小鼠的细胞毒性T细胞。缺乏多态性使这些分子成为肽疫苗的一个有前景的靶点。
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