Akusjärvi G
Dept of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden.
Trends Microbiol. 1993 Aug;1(5):163-70. doi: 10.1016/0966-842x(93)90085-6.
Of the more than 30 genes encoded by the adenovirus genome, no less than six have been shown to encode proteins that have transcription regulatory properties. None of them is a sequence-specific DNA-binding protein. They act to modulate the activity of cellular transcription factors by causing their phosphorylation or dephosphorylation, by physically interacting with them, or by dissociating transcription factor inhibitory protein complexes.
腺病毒基因组编码的30多种基因中，至少有6种已被证明可编码具有转录调节特性的蛋白质。它们都不是序列特异性DNA结合蛋白。它们通过使细胞转录因子磷酸化或去磷酸化、与它们进行物理相互作用或解离转录因子抑制蛋白复合物来调节细胞转录因子的活性。
