原发性葡萄膜黑色素瘤的细胞遗传学研究结果

Cytogenetic findings in primary uveal melanoma.

作者信息

Singh A D, Boghosian-Sell L, Wary K K, Shields C L, De Potter P, Donoso L A, Shields J A, Cannizzaro L A

机构信息

Oncology Service, Wills Eye Hospital, Philadelphia, Pennsylvania.

出版信息

Cancer Genet Cytogenet. 1994 Feb;72(2):109-15. doi: 10.1016/0165-4608(94)90125-2.

DOI:10.1016/0165-4608(94)90125-2

PMID:8143268

Abstract

We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.

摘要

我们分析了10例原发性葡萄膜黑色素瘤的细胞遗传学异常情况。9例存在克隆性染色体异常。6号染色体最常受累（7例），包括6号染色体物质增加和/或6q物质缺失。8号染色体三体或8q物质增加，大多表现为i(8q)，导致8q片段有三到五个拷贝，6例可见。3号染色体单体和9号染色体重排较少见，各有3例发生改变。临床、组织病理学和细胞遗传学异常相互关联。