Kimura T, Yamamoto G, Yoshitake K, Ando T
Department of Chemistry, Shiga University of Medical Science.
Jpn J Med Sci Biol. 1993 Jun;46(3):131-9. doi: 10.7883/yoken1952.46.131.
The present study revealed that the total fluoride level in human whole blood is closely related to the renal function. For the undialyzed patients who had not undergone hemodialysis, the total fluoride level in whole blood linearly increased with the increase of creatinine (Cr) value. The increased fluoride was found to be nonionic in the other blood part than serum, while the nonionic fluoride level in serum was almost constant. That is, the hemodialysis treatment finally reduced the nonionic fluoride level in the other blood part than serum. On the other hand, one hemodialysis treatment could excrete ionic fluoride, but not nonionic fluoride. These results suggest that the ionic fluoride is transformed to nonionic fluoride to be accumulated in other blood part than serum and the nonionic fluoride is transformed to the ionic fluoride to be excreted. Thus the accumulation of nonionic fluoride in other blood part than serum plays a role of the buffer in preventing a too high serum fluoride level.
本研究表明，人体全血中的总氟含量与肾功能密切相关。对于未接受血液透析的未透析患者，全血中的总氟含量随肌酐（Cr）值的增加而线性增加。在血清以外的其他血液部分中发现增加的氟是非离子性的，而血清中的非离子氟含量几乎恒定。也就是说，血液透析治疗最终降低了血清以外的其他血液部分中的非离子氟含量。另一方面，一次血液透析治疗可以排出离子氟，但不能排出非离子氟。这些结果表明，离子氟转化为非离子氟并在血清以外的其他血液部分中积累，而非离子氟转化为离子氟并被排出。因此，血清以外的其他血液部分中非离子氟的积累起到了防止血清氟水平过高的缓冲作用。
