Nicolay A, Bertocchio P, Bargas E, Coudoré F, Al Chahin G, Reynier J P
Laboratoire de Contrôle et de Fabrication, Hôpital Ste Marguerite, Marseille, France.
Clin Chim Acta. 1998 Jul 6;275(1):19-26. doi: 10.1016/s0009-8981(98)00066-7.
We have conducted a study of the elimination kinetics of fluoride ions by a log linear regression analysis of plasma levels obtained during a bicarbonate hemodialysis session, with a dialyzer in polymercaprin for six patients with chronic renal failure. Using plasma fluoride levels of 35 patients studied for 20 months, we have validated these kinetics for hemodialysis with sodium bicarbonate, acetate-free biofiltration, hemodiafiltration with low flow rate and other dialyzers. Our results show that the decrease in plasma fluoride levels is statistically significant only after the first hour, and the fall reaches approximately 30% after a 4 h dialysis session. We propose that post-dialysis measurements of plasma fluoride are now not necessary if levels before dialysis are known.
我们对6例慢性肾衰竭患者使用聚己内酯透析器进行碳酸氢盐血液透析期间获得的血浆水平进行对数线性回归分析，以研究氟离子的清除动力学。利用35例患者20个月的血浆氟水平，我们验证了碳酸氢盐血液透析、无醋酸盐生物滤过、低流量血液透析滤过及其他透析器的这些动力学。我们的结果表明，仅在第1小时后血浆氟水平的降低具有统计学意义，在4小时的透析疗程后下降约30%。我们建议，如果已知透析前的水平，现在不必进行透析后血浆氟的测量。
