Kataev S S, Vasil'eva N S, Avdeev V G, Gil'var L L, Starodvortseva V G, Zaĭrat'iants O V
Klin Med (Mosk). 1993;71(6):37-42.
Exocrinous performance of the pancreatic gland under secretin-pancreozymin stimulation was studied in 76 patients with chronic diffuse diseases of the liver who were distinguished into 6 groups: those who suffered from chronic persistent hepatitis of viral and alcohol origin, chronic active hepatitis of viral origin, cirrhosis of the liver of viral and alcohol origin, primary biliary hepatocirrhosis. The results obtained were correlated with those from 11 normal persons (controls). Out of 76 examinees the disorders of exocrinous performance of the pancreatic gland were revealed in 75 persons. The most characteristic features were: a decrease in the basal and an increase in the stimulated volume of the pancreatic juice; a reduction of both basal and stimulated production of bicarbonates; a decrease in the trypsin and amylase fasting levels and their increment in the stimulated juice of the pancreatic gland. Disorder in the production of bicarbonates was stated as a most characteristic feature in the patients both with viral and alcohol origin of the disease but it was mostly manifest in the patients with hepatocirrhosis. Pronounced elevation of the activity of amylase and trypsin in the pancreatic juice was observed in patients with very high activity of disease development and in the patients who continuously used large amounts of alcohol. The authors suspected that alcohol abuse and the effect of hepatitis virus had an equal pathogenic impact on the liver and pancreatic gland.
在76例慢性弥漫性肝病患者中研究了胰泌素-胰酶泌素刺激下胰腺的外分泌功能，这些患者被分为6组：患有病毒源性和酒精源性慢性持续性肝炎、病毒源性慢性活动性肝炎、病毒源性和酒精源性肝硬化、原发性胆汁性肝硬变的患者。将所得结果与11名正常人（对照组）的结果进行了对比。在76名受检者中，有75人存在胰腺外分泌功能障碍。最典型的特征是：基础胰液量减少，刺激后胰液量增加；基础和刺激状态下碳酸氢盐的分泌均减少；空腹时胰蛋白酶和淀粉酶水平降低，胰腺刺激后胰液中二者水平升高。碳酸氢盐分泌紊乱被认为是该疾病病毒源性和酒精源性患者最典型的特征，但在肝硬化患者中最为明显。在疾病进展非常活跃的患者以及持续大量饮酒的患者中，观察到胰液中淀粉酶和胰蛋白酶活性明显升高。作者怀疑，酗酒和肝炎病毒的作用对肝脏和胰腺具有同等的致病影响。
