Padmaja V, Thankamany V, Hisham A
Department of Chemistry and Environmental Microbiology, College of Engineering, Kerala, India.
J Ethnopharmacol. 1993 Dec;40(3):181-6. doi: 10.1016/0378-8741(93)90066-e.
On a pharmacological screening, substantial antibacterial, antifungal and anthelmintic activities were observed for the hexane and ethyl acetate extracts of the root barks of Uvaria narum Wall. and Uvaria hookeri King. Chromatographic fractionation of these extracts led to the isolation of the triterpenes glutinol, glutinone, taraxerol, beta-sitosterol and Annonaceous acetogenins uvariamicins-I, II and III mixture, isodesacetyluvaricin, squamocin-28-one, narumicins-I and II stereoisomeric mixture, squamocin and panalicin. The acetogenins exhibited antimicrobial and anthelmintic activities in their individual screening comparable with standard drugs and hence their presence could be attributed to a great extent for the biocidal properties of U. narum and U. hookeri extracts.
在一次药理筛选中，观察到紫玉盘（Uvaria narum Wall.）和滇南紫玉盘（Uvaria hookeri King.）根皮的己烷提取物和乙酸乙酯提取物具有显著的抗菌、抗真菌和驱虫活性。对这些提取物进行色谱分离，得到了三萜类化合物谷甾醇、谷甾酮、蒲公英赛醇、β-谷甾醇以及番荔枝类产乙酸素紫玉盘素-I、II和III混合物、异去乙酰紫玉盘素、番荔枝辛酮-28-酮、紫玉盘素-I和II立体异构体混合物、番荔枝辛和帕纳利辛。在各自的筛选中，产乙酸素表现出与标准药物相当的抗菌和驱虫活性，因此它们的存在在很大程度上可归因于紫玉盘和滇南紫玉盘提取物的杀菌特性。
