Uluitu M, Duşleag L, Constantinescu D, Petcu G, Catrinescu G, Pană S
Physiologie. 1975;12(4):275-80.
By spectrofluorimetric method there was followed the blood and cerebral serotonin content in different species of mammalians: in 28 women, from the venous whole blood collected by cubital puncture, and in 20 cows, from the jugular whole blood. In 90 female rats the serotonin content from hypothalamus, rhinencephalon, mesencephalon, and sensorimotor cortex was determined. The obtained data show that in the course of labour in both species the blood serotonin concentration is decreased, returning to its initial values after delivery. The serotonin concentration in cows is 10--15 times higher than in women. As concerns the serotonin values in the cerebral nuclei through pregnancy, a progressive and significant increase of its content was noted in the hypothalamus, rhinencephalon, and mesencephalon, but not in the cerebral cortex. It reaches its maximum concentration at the end of pregnancy. It was concluded that during pregnancy a reduction of serotonin release processes is produced, which can signify a lower functional level of the serotoninergic structures implied in the regulation of the reproductive functions. The data are interpreted in the light of the particular endocrine state existing through pregnancy, attributing to serotonin a role in the functioning of PIF-prolactin system.
对28名女性，通过肘静脉穿刺采集全血进行检测；对20头奶牛，采集颈静脉全血进行检测。对90只雌性大鼠测定了下丘脑、嗅脑、中脑和感觉运动皮层中的血清素含量。所获数据表明，在这两个物种的分娩过程中，血液中血清素浓度均降低，分娩后恢复至初始值。奶牛的血清素浓度比女性高10至15倍。关于整个孕期大脑核团中的血清素值，在下丘脑、嗅脑和中脑中观察到其含量有逐渐且显著的增加，但大脑皮层中未出现这种情况。在孕期结束时达到最高浓度。得出的结论是，孕期会出现血清素释放过程的减少，这可能意味着参与生殖功能调节的血清素能结构的功能水平较低。根据孕期存在的特定内分泌状态对这些数据进行了解释，认为血清素在促乳素抑制因子 - 催乳素系统的功能中发挥作用。
