Uluitu M, Lazăr M, Catrinescu G
Physiologie. 1976 Apr-Jun;13(2):145-53.
By researches carried out in male adult rats (Wistar), the influence of the intraperitoneally injected bufotenin (5 mg/kg b.w. active substance in saline solution) was followed on: I--feeding behavior; II--the serotonin concentration in hypothalamus, rhinencephalon, mesencephalon and sensorimotor cerebral cortex. The obtained results show that bufotenin influences the feeding behavior by reducing the motor functions. Its action depends on the physiological state of the animal: by increasing the alimentary motivation the rats can escape the bufotenin influence, showing a normal behavior; bufotenin does not influence the sensorials, the natural dispositions and the excitability level of the feeding and satiety hypothalamic centers. Bufotenin increases serotonin concentration only in the mesencephalic region, but not in the other studied regions. The results are interpreted as a primary bufotenin action on the serotoninic vasoconstrictive receptors at the mesencephalic level, thus disturbing the serotonin-releasing processes and possibly other chemical neurotransmitters.
通过对成年雄性Wistar大鼠进行的研究，观察腹腔注射蟾蜍色胺（在盐溶液中活性物质为5毫克/千克体重）对以下方面的影响：I——进食行为；II——下丘脑、嗅脑、中脑和感觉运动性大脑皮质中的血清素浓度。所得结果表明，蟾蜍色胺通过降低运动功能来影响进食行为。其作用取决于动物的生理状态：通过增加进食动机，大鼠可以避免蟾蜍色胺的影响，表现出正常行为；蟾蜍色胺不影响感觉、自然倾向以及进食和饱腹感下丘脑中枢的兴奋水平。蟾蜍色胺仅增加中脑区域的血清素浓度，而在其他研究区域则无此作用。这些结果被解释为蟾蜍色胺在中脑水平对血清素能血管收缩受体的主要作用，从而干扰血清素释放过程以及可能的其他化学神经递质。
