Uluitu M, Boca A, Petec G, Chis R, Catrinescu G
Physiologie. 1981;18(3):167-74.
By researches carried out in adult female rats we followed the effect of chronic administration of malathion on the serotonin level from hypothalamus, rhynencephalon, mesencephalon and cerebral cortex and on the hypophysio-ovarian system. The obtained results showed that malathion produces: 1) the increase of cerebral serotonin level through the active phases of the gonadal cycle (proestrus + oestrus); 2) the increase of the percent incidence of the gonadal active phases; 3) the decrease of the LH synthesis through the oestral cycle; 4) the increase of the FSH release during the active phases and the decrease of the LH release in the inactive phases of the ovarian cycle. The data show that malathion influences the reproductive function both by its cellular toxic action and by affecting the encephalic regulatory serotoninergic, besides acetylcholinergic, mechanism of the reproductive functions.
通过在成年雌性大鼠身上开展的研究，我们追踪了长期施用马拉硫磷对下丘脑、端脑、中脑和大脑皮质中血清素水平以及对垂体 - 卵巢系统的影响。所得结果表明，马拉硫磷会产生：1）在性腺周期的活跃阶段（动情前期 + 发情期）使大脑血清素水平升高；2）性腺活跃阶段的发生率百分比增加；3）在整个发情周期中促黄体生成素（LH）合成减少；4）在卵巢周期的活跃阶段促卵泡生成素（FSH）释放增加，而在非活跃阶段促黄体生成素（LH）释放减少。数据表明，马拉硫磷不仅通过其细胞毒性作用，还通过影响生殖功能的脑调节血清素能机制（除乙酰胆碱能机制外）来影响生殖功能。
