Nakashima E
Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
Radiat Res. 1994 Apr;138(1):121-6.
Five body measurements--standing height, body weight, sitting height, chest circumference and intercristal diameter--of 18-year-old atomic bomb survivors exposed in utero in Hiroshima and Nagasaki were analyzed in relation to DS86 uterine dose. Age in utero was divided into four periods: 0-7, 8-15, 16-25 and > or = 26 weeks. This categorization is based upon the study of radiation-induced brain damage. The linear regression analyses for these five variables showed significant decreases with increasing dose. The regression coefficients were -2.65 cm/Gy for standing height, -2.46 kg/Gy for body weight, -0.92 cm/Gy for sitting height, -1.37 cm/Gy for chest circumference and -0.32 cm/Gy for intercristal diameter. The multivariate test statistic for the overall dose effect on five body measurements was significant, but the interaction between dose and gestational period was not significant. Principal-component analysis was applied to the five variables. For the first-component scores, the dose effect was significant, but the interaction between dose and gestational period was not significant. For the second-component scores, the dose effect was significant specifically at 0-7 weeks. The radiation dose effect on the second principal component found at 0-7 weeks of gestation suggests that malformations occur in this period.
对广岛和长崎子宫内受照的18岁原子弹幸存者的五项身体测量指标——身高、体重、坐高、胸围和髂嵴间径，与DS86子宫剂量进行了相关性分析。子宫内年龄分为四个时期：0 - 7周、8 - 15周、16 - 25周和≥26周。这种分类基于对辐射诱发脑损伤的研究。对这五个变量进行的线性回归分析显示，随着剂量增加，各指标显著下降。回归系数分别为：身高-2.65厘米/戈瑞、体重-2.46千克/戈瑞、坐高-0.92厘米/戈瑞、胸围-1.37厘米/戈瑞、髂嵴间径-0.32厘米/戈瑞。五项身体测量指标总体剂量效应的多变量检验统计量具有显著性，但剂量与孕期之间的交互作用不显著。对这五个变量进行了主成分分析。对于第一主成分得分，剂量效应显著，但剂量与孕期之间的交互作用不显著。对于第二主成分得分，剂量效应在0 - 7周时尤为显著。在妊娠0 - 7周时发现的辐射剂量对第二主成分的影响表明，在此期间会出现畸形。
