一项关于香港华裔献血者中米尔滕贝格抗体发生率的调查。

A survey of the incidence of Miltenberger antibodies among Hong Kong Chinese blood donors.

作者信息

Mak K H, Banks J A, Lubenko A, Chua K M, Torres de Jardine A L, Yan K F

机构信息

Hong Kong Red Cross Blood Transfusion Service.

出版信息

Transfusion. 1994 Mar;34(3):238-41. doi: 10.1046/j.1537-2995.1994.34394196622.x.

DOI:10.1046/j.1537-2995.1994.34394196622.x

PMID:8146897

Abstract

BACKGROUND

The ready availability of red cells of the Miltenberger (Mi) class III phenotype (6.28%) prompted the study of Mi antibodies among Chinese blood donors in Hong Kong, 98 percent of whom are descended from inhabitants of Guangdong Province in southern China.

STUDY DESIGN AND METHODS

Red cells of the Mi class III phenotype were used to conduct a survey of the frequency of Miltenberger antibodies in 56,161 random Chinese blood donors, over a period of 12 months, using a microplate technique.

RESULTS

Sera from 32 donors (0.057%) were found to contain Mi antibodies: sera from 22 contained anti-Mur + Hut; sera from 4 contained anti-Vw + Mur + Hut; sera from 4 had monospecific anti-Mur; and sera from 2 had monospecific anti-Hil. The immunoglobulin isotypes of 24 sera were mixtures of IgM and IgG, 4 were pure IgM, and 4 were pure IgG.

CONCLUSION

The majority of Mi antibodies detected were naturally occurring. This survey proved useful for mass screening of random donors for the procurement of valuable Mi antisera.

摘要

背景

米尔滕贝格（Mi）III类血型（6.28%）红细胞的易得性促使对香港中国献血者中的Mi抗体进行研究，其中98%的献血者是中国南方广东省居民的后裔。

研究设计与方法

在12个月的时间里，使用微孔板技术，用Mi III类血型红细胞对56161名随机抽取的中国献血者进行米尔滕贝格抗体频率调查。

结果

发现32名献血者（0.057%）的血清中含有Mi抗体：22名献血者的血清中含有抗Mur + Hut；4名献血者的血清中含有抗Vw + Mur + Hut；4名献血者的血清中有单特异性抗Mur；2名献血者的血清中有单特异性抗Hil。24份血清的免疫球蛋白同种型为IgM和IgG的混合物，4份为纯IgM，4份为纯IgG。