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非精原细胞瘤性睾丸癌的保留神经腹膜后淋巴结切除术

[Nerve preserving retroperitoneal lymph node excision in non-seminomatous testicular cancer].

作者信息

Hofmann R, Hartung R, von Stauffenberg A

机构信息

Urologische Klinik und Poliklinik, Technischen Universität München, Klinikum rechts der Isar.

出版信息

Urologe A. 1994 Jan;33(1):38-43.

PMID:8146929
Abstract

Thirty-nine patients with a non-seminomatous testicular tumor underwent retroperitoneal lymphadenectomy (RPLND) between 12/90 and 7/93. Twenty-four patients with stage I disease were operated on with a modified nerve-sparing RPLND, while 7 patients with stage IIA and 8 patients with stage IIB had bilateral RPLND. Twelve of fifteen patients with stage IIA and IIB had preservation of their sympathetic postsynaptic fibers. Intraoperative electric stimulation of the fibers resulted in ejaculation in 25/26 patients. Semen analysis revealed 21 patients with necrospermia and maturation arrest, while 3 had aspermia. Antegrade ejaculation was restored after 1.1 months following nerve-sparing RPLND and 7 months following radical RPLND. Ejaculation did not return in one patient. No patient showed relapse. Our results show that the sympathetic postsynaptic fibers can be preserved during RPLND. Nerve-sparing RPLND is superior to radical and modified RPLND with regard to preservation of ejaculation without compromising the radicalness of the tumor surgery.

摘要

1990年12月至1993年7月期间,39例非精原细胞瘤性睾丸肿瘤患者接受了腹膜后淋巴结清扫术(RPLND)。24例I期疾病患者接受了改良保留神经的RPLND手术,而7例IIA期和8例IIB期患者接受了双侧RPLND。15例IIA期和IIB期患者中有12例保留了其交感神经节后纤维。术中对这些纤维进行电刺激,26例患者中有25例出现射精。精液分析显示,21例患者存在死精症和成熟停滞,3例无精子症。保留神经的RPLND术后1.1个月以及根治性RPLND术后7个月,顺行射精得以恢复。1例患者射精未恢复。无患者出现复发。我们的结果表明,在RPLND过程中可以保留交感神经节后纤维。在保留射精功能方面,保留神经的RPLND优于根治性和改良RPLND,且不影响肿瘤手术的根治性。

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